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EXPERIMENT INFORMATION

Morphological and Biochemical Investigations of Microgravity-Induced Nerve and Muscle Breakdown: I. Investigation of Nerve and Muscle Breakdown During Spaceflight (COS 1887-6)
Principal Investigator
Research Area:
Muscle physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Extended human exposure to microgravity produces progressive skeletal muscle weakness. The mechanism of the loss must be understood in order to develop rational countermeasures. While simple atrophy should be reversible by exercise, restoration of pathological changes depends upon complex processes of regeneration. This study attempted to further the understanding of the effects of space flight on muscle weakness.


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Publications
Riley, D.A. et al.: Morphological and Biochemical Investigations of Microgravity-Induced Nerve and Muscle Breakdown: I. Investigation of Nerve and Muscle Breakdown During Spaceflight. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 1887. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-102254, 1990, pp. 215-257.

Riley, D.A. et al.: Skeletal Muscle Fiber, Nerve, and Blood Vessel Breakdown in Space-Flown Rats. FASEB Journal, vol. 4, no. 1, 1990, pp. 84-91.

Riley, D.A.: Effects of Microgravity on Rat Muscle. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 1887. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-102254, 1990, pp. 45-49.

Keywords
Adenosinetriphosphatase (ATPase)
Motor neurons
Muscle fibers
Muscle fibers, fast-twitch
Muscle fibers, slow-twitch
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Area, cross section, Capillaries, adductor longus, muscle, rat, Histology, microscopy
Area, cross section, Extensor digitorum longus, muscle, rat, Histology, microscopy
Area, cross section, Plantaris, muscle, rat, Histology, microscopy
Area, cross section, Soleus, muscle, rat, Histology, microscopy
Count, Macrophage, adductor longus, muscle, rat, Microscopy
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1887 09/29/1987 10/11/1987 13 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1887-10.1
Protocol / Approach
Hardware Items