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EXPERIMENT INFORMATION

Morphological and Biochemical Investigations of Microgravity-Induced Nerve and Muscle Breakdown: II. Biochemical Analysis of EDL and PLT Muscles (COS 1887-21)
Principal Investigator
Research Area:
Muscle physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Carbonic anhydrase III (CA III) is present in highest concentrations in slow oxidative muscle fibers whereas fast fibers have very low concentrations, and the levels of the enzyme can be affected by a number of physiological perturbations. Although the plantaris (PLT) and the extensor digitorum longus (EDL) are quite gravity insensitive, it was of interest to determine the influence of space flight on levels of CA III. Conversely, parvalbumin (PVA) is highest in concentration in the fast twitch muscle and functions as a relaxing factor facilitating the sequestration of calcium in the sarcoplasmic reticulum. In view of reports that unloading slows the 1/2 relaxation time, it was also of interest to measure possible concentration decreases of this protein.


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Publications
Ellis, S. et al.: Morphological and Biochemical Investigations of Microgravity-Induced Nerve and Muscle Breakdown: II. Biochemical Analysis of EDL and PLT muscles. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 1887. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-102254, 1990, pp. 259-261.

Keywords
Carbonate dehydratase
Muscle fibers
Enzymes
Parvalbumins

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Activity, enzymic, Cytosolic anhydrase III, plantaris, extensor digitorum longus, muscle, rat, Assay
Activity, enzymic, Tripeptidyl aminopeptidase (TAP), plantaris, extensor digitorum longus, muscle, rat, Assay
Activity, enzymic, Various, extensor digitorum longus, muscle, rat, Synthetic peptides (units)
Activity, enzymic, Various, plantaris, muscle, rat, Synthetic peptides (units)
Content, Parvalbumin, in plantaris (PLT) and extensor digitorum longus (EDL), muscle, rat

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1887 09/29/1987 10/11/1987 13 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1887-10.2
Protocol / Approach
Hardware Items