During STS-86's docked phase, water, food and other resupply items, along with Mir 24/NASA 6 research hardware and equipment was transferred from the Shuttle to Mir. A 6-hour extra vehicular activity (EVA) also took place during the docked phase to retrieve scientific hardware.
Thirty-six investigations in 6 disciplines were performed during the NASA 6 mission. These disciplines were human life sciences, microgravity sciences, space biology, advanced technology, International Space Station (ISS) risk mitigation, and Earth sciences.
Human life sciences experiments investigated human responses to long duration space flight and readaptation to Earth's gravity in the areas of bone mineral density, muscle volume, crew interactions, immune response, autonomic function, and the role of sleep in circadian rhythms.
Microgravity sciences experiments characterized the Mir microacceleration environment, and studied material sciences to gain a better understanding of physical processes in microgravity. Some experiments also used the microgravity environment and various growth methods in protein crystal studies and biochemistry 3-D tissue engineering.
The single space biology investigation studied the overall radiation environment inside and outside of the Mir Space Station, as well as the dosages received by the station.
Advanced technology investigations examined alloy formation in microgravity and tested temperature controlled life sciences cell research modules.
Experiments in the ISS risk mitigation discipline evaluated the structural dynamics of a complex space vehicle, such as how crew activities impacted the structure of the vehicle. Some also tested materials, hardware, facilities, and operational techniques planned for the International Space Station.
Earth sciences experiments analyzed biospheric and atmospheric temporal and seasonal changes over several oceanic and land-based test sites using both hand-held photography and remote sensing instrumentation aboard the Mir Priroda module, and photodocumented internal and external window surfaces.
Nearly all Shuttle-Mir investigations were joint efforts between the United States and Russia. In addition to the benefits of international cooperation, the NASA 6 mission added to the understanding of many scientific areas, including how living organisms are affected during long-duration space flight. Despite the setbacks experienced during NASA 5, the Mir 24/NASA 6 crew and ground-based teams made the necessary repairs to the Mir station and were well on their way to re-establishing a successful science research program to continue the study of life sciences in space.