Expedition 53 began September 2, 2017 with the handover of command by Expedition 52 commander Fyodor Yurchikhin (RSA) to Expedition 53 commander, Randy Bresnik (NASA). Shortly thereafter, Expedition 52 crew members Yurchikhin, Peggy Whitson (NASA), and Jack Fischer (NASA) departed the station on a Soyuz MS-04 spacecraft and returned to Earth.
With Bresnik, flight engineers Paolo Nespoli (ESA) and Sergey Ryazanskiy (RSA) continue to operate the station. They will be joined on September 13, by Joseph Acaba (NASA), Mark Vande Hei (NASA), and Alexander Misurkin (RSA), completing the Expediton 53 crew. Acaba, Vande Hei, and Misurkin will launch September 12 on a Soyuz MS-06 spacecraft.
Expedition 53 concluded December, 2017.