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Ground Based Study:    MEDES
MEDES Space Clinic
Launch/Start Date:
Landing/End Date:
312 days

Within the frame of the utilization of the International Space Station, the French (CNES), European (ESA), Canadian (CSA) and American (NASA) space agencies decided to join their efforts to organize ground based simulations of international space station flights, using the anti orthostatic bed rest model. The agencies are members of the International Space Life Sciences Working Group (“ISLSWG”), working together in developing and maintaining an International Strategic Plan for the Space Life Sciences and to effectively implement multilateral research programs. The Women International Space Simulation for Exploration (WISE) study was carried out by MEDES, the French Institute of Medicine and Space Physiology, at its clinical research facility in the Rangueil hospital in Toulouse, France. The role of nutrition and physical exercise in countering the adverse effects of prolonged gravitational unloading during bed-rest was assessed.

The data collected by WISE was the basis of findings relating to specific areas including muscle condition, blood parameters, cardiovascular condition, and changes in the immune system, bone formation and psychological wellbeing. The results expected from WISE will be valuable to the planning of future long-duration human space exploration missions.

Experiment data collection was performed on twelve subjects per campaign. Baseline data collection was performed beginning twenty days prior to Head Down Tilt (HDT) Bed Rest. Data collection was performed during the HDT phase of the study. Post HDT data collection began on the first day of the Recovery Period (R+0) and continued for twenty days. Follow on studies were scheduled at 45, 90, 180 and 360 days following the end of the HDT portion of the study.

Pre-HDT Bed Rest and post HDT Bed Rest data collection activities supported experimental protocols by obtaining scientific data in order to establish reference levels of physiological and psychological parameters and the time course of changes from and/or return to those levels.

The bed rest study had the following main objectives:

• Evaluation of exercise and nutrition countermeasures using a collection of standard baseline data before, during and after long term bed rest,
• Identify specific patterns in the response of the female physiology to prolonged musculoskeletal unloading and induced cardiovascular deconditioning,
• Understanding of other physiological mechanisms that are responsible for spaceflight-related biomedical and behavioral changes in humans in support of countermeasure development.

In addition to the six Standard Measures testing which was shared to investigators, twelve investigations were conducted during this mission:

  • Treadmill Exercise within LBNP
    (PI: Alan R. Hargens, Ph.D., University of California, San Diego UCSD Medical Center)

  • Muscle Protocol
    (Pis: Yvonne Mounier, Ph.D., Université des Sciences et Technologies de Lille France; Scott Trappe, Ph.D., Ball State University, Muncie, IN; Dieter Blottner, Ph.D., Charité University Medicine, Berlin, Germany; and Angèle Choppard Ph.D., Université de Nice, France)

  • Nutritional and exercise interventions in long-term bed rest
    (PI: Gianni Biolo, MD, Ph.D., Department of Clinical, Morphological and Technological Sciences, Division of Internal Medicine, University of Trieste)

  • Effect of exercise on energy partitioning and lipids trafficking during simulated weightlessness in women
    (PI: Stéphane Blanc, Ph.D., Centre d’Ecologie et Physiologie Energétiques)

  • Vascular remodeling and functional consequences after Long-Term Bed Rest
    (PI: Richard L. Hughson, Ph.D., Cardio-respiratory and Vascular Dynamics Laboratory Faculty of Applied Health Sciences University of Waterloo)

  • Development of asymptomatic thrombosis during prolonged bed rest
    (PI: F.R. Rosendaal, MD, Ph.D., Department of Clinical Epidemiology Leiden University Medical Center)

  • Bed Rest and Immunity
    (PI: Gerald Sonnenfeld, Ph.D., Binghamton University)

  • Alterations of Steroidgenesis by Exercise Countermeasures during Bed Rest
    (PI: Charles E. Wade, Ph.D., USAISR- MTR)

  • Bed rest-related changes in the postural and gait modulation of lumbar group II propriospsinal pathways
    (PI: Marque Philippe M.D., Ph.D., Service de médecine physique et de réadaptation – CHU Rangueil)

  • Musculoskeletal limitations to physical activity in simulated weightlessness
    (PI: Guy Trudel, MD, Ph.D., FRCPC Department of Medicine, University of Ottawa the Rehabilitation Centre)

  • Psychological investigations of adaptation and well-being
    (PI: Karine Weiss, Ph.D., Laboratoire de Psychologie Environnementale Université Paris)

  • Aerobic & Anaerobic Exercise & Diet
    (PIs: Dieter Felsenberg Ph.D., Centre of Muscle & Bone Research, Charité and Christian Alexandre M.D., Ph.D., Laboratoire de Biologie du Tissu Osseux University Medicine Berlin, Campus Benjamin Franklin)