Research Subheader

Shuttle Life Sciences Research (Middeck)

Life sciences research was prolific within the Space Shuttle program between 1991 and 1995. In this five-year period, 21 Space Transportation System (STS) missions carried life sciences experiments into Earth orbit. The Shuttle program provided the life sciences research community increased access to space due to the practicality of small payloads. The location of small payloads in the middeck allowed for late loading before launch and early recovery after landing. Quick postflight access allowed researchers to examine the effects of microgravity on living systems before the organisms readapt to Earth gravity. Use and reuse of existing hardware minimizes development costs and the lag time between initial experiment proposal and actual flight. These payloads were flown with short preparation time, allowing investigators to repeat experiments and verify data on subsequent missions. Significant crew interaction with experiments was not possible since the middeck has no laboratory facilities. Size, weight, safety, and containment restrictions were especially important because small middeck payloads share space with crew living quarters.

Photo Gallery

Related Experiments
Links
  + Effects of Zero Gravity on Biochemical and Metabolic Properties of Skeletal Muscle Fiber-Types (178127 2_3)
  + The Effects of Micro-Gravity on Bone Cell Cultures (9304021 2_2)
  + Developmental and Physiological Processes Influencing Seed Set in Microgravity (8913052 1_2)
  + Effects of Microgravity on Tobacco Hornworm (Manduca sexta) During Metamorphosis (8913078 1_2)
  + Effects of Microgravity on Tobacco Hornworm (Manduca Sexta) During Metamorphosis (8913078 2_2)
  + Development of Vestibular Organs in Microgravity (9301004 1_2)
  + The Effect of Spaceflight on Cartilage Cell Cycling and Differentiation (9601378)
  + Effects of Weightlessness on Vestibular Development (9303003)
  + Effect of Spaceflight on Development of Immune Responses (9303009)
  + Choroid Plexus, Brain and Heart Natriuretic Peptide Development in Space (9303011)
  + Microgravity and Placental Development (9303012)
  + Histological Effects of Microgravity on Rat Body Wall Musculature (9303017)
  + Effects of Spaceflight on Muscles and Nerves (9303019)
  + Effects of Gravity on the Attachment of Tendon to Bone (9303021)
  + Effects of Spaceflight on the Development of the Circadian Timing System (9303024)
  + Effects of Microgravity on Bone Development (9303025)
  + An Experiment to Study the Role of Gravity in the Development of the Optic Nerve (9303026)
  + Effect of Microgravity on Epidermal Development in the Rat (9303028)
  + Neuromuscular Development and Regulation of Myosin Expression (9303030)
  + Spaceflight Effects on Mammalian Development (9303031 1_2)
  + Spaceflight Effects on Mammalian Development (9303031 2_2)
  + Effect of Spaceflight on TGF-Beta Expression by hFOB Cells (9304007 1_2)
  + Effect of Spaceflight on TGF-Beta Expression by hFOB Cells (9304007 2_2)
  + Effect of Space Travel on Skeletal Myofibers (9304010 2_3)
  + Effect of Space Travel on Skeletal Myofibers (9304010 3_3)
  + The Effects of Hypogravity on Osteoblast Differentiation (9304011 1_2)
  + The Effects of Hypogravity on Osteoblast Differentiation (9304011 2_2)
  + The Effects of Micro-Gravity on In Vitro Calcification (9304016 1_3)
  + The Effects of Micro-Gravity on In Vitro Calcification (9304016 2_3)
  + The Effects of Micro-Gravity on In Vitro Calcification (9304016 3_3)
  + Molecular and Cellular Analysis of Space Flown Myoblasts (9304018 1_2)
  + Molecular and Cellular Analysis of Space Flown Myoblasts (9304018 2_2)
  + Effect of Spaceflight on Microbial Gene Expression and Virulence (Microbe) (2001092)
  + Osteoblast Adhesion and Phenotype in Microgravity (9304022 1_2)
  + Osteoblast Adhesion and Phenotype in Microgravity (9304022 2_2)
  + Microgravity Effects on Early Reproductive Development in Plants (9305001)
  + Somatic Embryogenesis of Orchardgrass in Microgravity (9305005)
  + Regulation of Cell Wall Polymers by Microgravity (9305007)
  + Plant Embryos and Fidelity of Cell Division in Space (9305010 1_2)
  + Genetically Engineered Plant Biomonitors in Microgravity (9305020)
  + Lignin Formation and Effects of Microgravity: a New Approach (9307247)
  + Cellular Signal Perception and Signal Transduction (9307385)
  + Calcium Metabolism and Vascular Function in Rats after Spaceflight (9401686)
  + Microgravity Effects during Fertilization, Cell Division, Development, and Calcium Metabolism in Sea Urchins (95010376)
  + Brain Pituitary Axis Development in the CEBAS Minimodule (9501137)
  + Gravity Effects on Seedling Morphogenesis (95020023)
  + Bacterial Physiology and Virulence on Earth and in Microgravity (ARC00XX17)
  + Drug Resistance and Virulence (MDRV): Saccharomyces cerevisiae Gene Expression and Susceptibility to Voriconazole During Spaceflight (ARC00XX18)
  + Differentiation of Bone Marrow Macrophages in Space (BONEMAC) (9604071)
  + Development of Gravity Sensitive Plant Cells (Ceratodon) in Microgravity (9601445)
  + Role of Interleukin-2 Receptor in Signal Transduction and Gravisensing Threshold in Lymphocytes (Leukin) (9604156)
  + Synaptogenesis in Microgravity (9301042 2_2)
  + Plant Carry on Container (SLSTP85)
  + Skeletal Development in Embryonic Quail (9802307)
  + Anatomical Studies of Central Vestibular Adaptation: Neurolab Completion Proposal (9301127 2_2)
  + Bacterial Physiology and Virulence on Earth and in Microgravity (9604406)
  + Arterial Remodeling and Functional Adaptations Induced by Microgravity (9802386)
  + Choroidal Regulations Involved in the Cerebral Fluid Response to Altered Gravity: Water Transports and Serotonergic Receptors (9802409)
  + Development of Sensory Receptors in Skeletal Muscle (9303006)
  + Effect of Space Travel on Skeletal Myofibers (9304010 1_3)
  + Influence of Spaceflight on Bone Cell Cultures (9304021 1_2)
  + Effect of Weightlessness on Bone Histology, Physiology, and Mechanics (CPPSE02)
  + Effect of Weightlessness on Tissue Regeneration in Rodents (CPPSE03)
  + Role of the Immune System in Mediating Bone Turnover in Ovariectomized Rats in Microgravity (CPPSE04)
  + Characterization of Neurospora crassa Circadian Rhythms (CNCR) in Space (DC84LS02)
  + Microgravity-Induced Effects on Pituitary Growth Hormone Cell Function (PHCF): A Mechanism for Muscle Atrophy in Manned Space Flight (DC84LS12)
  + Cell Kenetic and Histomorphometric Analysis of Microgravitational Osteopenia (DC85LS03)
  + Acute Adaptation of Bone to Spaceflight (DC85LS04)
  + Physiological and Anatomical Rodent Experiment 1 (DC85LS27)
  + Plant Metabolism and Cell Wall Formation in Space (Microgravity) and on Earth (DCL92TH)
  + Development and Function of the Avian Otolith System in Normal and Altered Gravity Environments (9802272)
  + Rodent Dam/Neonate Animal Enclosure Module Nursing Facility Development Experiment (E122A)
  + Behavior of Postnatal Rats After Space Flight (E122B)
  + Effects of Microgravity on Growth Hormone Concentration and Distribution in Plants (GHCD-1)
  + Fluid Electrolyte Metabolism (PARE.04A)
  + Skeletal Development (PARE.04B)
  + Developmental Abnormalities (PARE.04C)
  + Fungal Pathogenesis, Tumorigenesis, and Effects on Host Immunity in Space (FIT) (ARC00XX6)
  + Cabin Air Monitoring (DTO 623)
  + The Impact of Spaceflight on Arabidopsis: Deep Sequencing and DNA Arrays as Collaborative Readouts of the Transcriptome of Arabidopsis Seedlings and Undifferentiated Cells in Space (NNX11AE48G)
  + Actin Regulation of Arabidopsis Root Growth and Orientation During Spaceflight (NNX10AF43G)
  + Effect of Spaceflight on Microbial Gene Expression and Virulence (Microbe) (ARC00XX15)
  + Antigen-Specific CD4+ T Cell Priming and Memory Response During Spaceflight (ARC00XX19)
  + The Effects of Microgravity on the Tissue Regenerative Potential of Stem Cells - Space Tissue Loss Stem Cell Regeneration (STL-SCR) (ARC00XX44)
  + Space Tissue Loss Innate Mammalian Mechanisms Universal Novel Expressions (STL-IMMUNE) (ARC00XX45)
  + The Effects of Microgravity on Stem Cell-Based Tissue Regeneration: Keratinocyte Differentiation in Wound Healing (STL) (ARC00XX51)
  + Gravitational Effects on Biofilm Formation During Spaceflight (Micro-2) (ARC00XX46)
  + Gravitational Effects on Biofilm Formation During Spaceflight (Micro-2A) (ARC00XX75)
  + Drosophila as a Model of Immune Function in Conditions of Altered Gravitational Force (NNA04CC76A)