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Non-exercise Physiological Countermeasure (NxPCM) Project

The Non-exercise Physiological Countermeasure (NxPCM) Project is an ongoing project-focused body of research which develops, evaluates, validates, and implements technologies for risk assessment and mitigation, as well as countermeasures for health and safety risks relevant to planned space exploration. The project goal is to help ensure crewmember health and safety, by gaining knowledge and developing technologies to advance NASA's practice of evidence-based medicine, and by providing methods and technologies that enable NASA to safely and effectively use products, procedures, and strategies to prevent or minimize systemic physiological changes caused by spaceflight. NxPCM areas of responsibility include bone, muscle, cardiovascular, sensory-motor, nutrition, pharmacotherapeutics, and immunology/infection/hematology. Research efforts leading to contributing knowledge to generate crew health and medical requirements and standards will be coordinated to avoid duplication of efforts and to ensure fiscal resources are optimized.

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  + Nutritional Status Assessment (SMO 016E)
  + Foot Reaction Forces During Space Flight (96-E318)
  + Promoting Sensorimotor Response Generalizability (98-E120)
  + Subregional Assessment of Bone Loss in the Axial Skeleton in Long-Term Space Flight (96-E343)
  + Bone and Muscle Recovery from Simulated Microgravity (NCC958BL00205)
  + Renal Stone Risk During Space Flight: Assessment and Countermeasure Validation (96-E057)
  + Effect of Prolonged Space Flight on Human Skeletal Muscle (96-E400)
  + Chromosomal Aberrations in Blood Lymphocytes of Astronauts (99-E010)
  + Test of Midodrine as a Countermeasure Against Postflight Orthostatic Hypotension (SMO 006)
  + Bioavailability and Performance Effects of Promethazine (PMZ) During Space Flight (DSO 490)
  + Advanced Diagnostic Ultrasound in Microgravity (ILSRA-2001-083)
  + Gastrointestinal Absorption and Pharmacokinetics in Astronauts (DSO 632)
  + Space Flight Induced Reactivation of Epstein-Barr Virus (98-E129)
  + Cardiovascular and Cerebrovascular Control on Return from International Space Station (CCISS) (E117)
  + Immune Function Changes During a Spaceflight-analog 12-day Undersea Mission (ROI_Immune)
  + Cardiac Atrophy and Diastolic Dysfunction During and After Long-Duration Spaceflight: Functional Consequences for Orthostatic Intolerance, Exercise Capacity, and Risk of Cardiac Arrhythmias (99-E377)
  + Space Flight and Immune Function (DSO 498)
  + Monitoring Latent Virus Reactivation and Shedding in Astronauts (DSO 493)
  + Spatial Reorientation of Sensorimotor Balance Control in Altered Gravity (DSO 635)
  + Bisphosphonates As A Countermeasure To Space Flight Induced Bone Loss (SMO 021)
  + Validation of Procedures for Monitoring Crewmember Immune Function (SMO 015)
  + Vestibular-Cerebrovascular Interactions and Their Contribution to Post-Spaceflight Orthostatic Intolerance (NNJ04HI13G)
  + Hypovolemia As a Model of Space Flight: Cardiovascular Effects and Countermeasures (SMOg HYPOVOLEMIA)
  + Effects of Simulated Microgravity on the Anesthetic Properties of Propofol (NNJ04HF74G)
  + Assessment of Pharmaceutical Stability in Space Using Ground-based Simulation of Spacecraft Environmental Factors (BRC04-JSC01)
  + Efficacy of Vitamin D Supplementation in an Antarctic Ground Analog of Space Flight (ROI_VITAMIN_D)
  + Multisensory Interactions to Discriminate Gravity From Translational Acceleration (NNA04CC77G)
  + Gravitational Influence on Cerebellar Control of Gaze Movement and Adaptation (NNA04CC60G)
  + Virtual Reality Training: Cybersickness and Effects on Sensorimotor Functions (BRC04-JSC02)
  + Investigation of Neural Strategies of Visual Search (NAG91465)
  + Head-eye Coordination During Simulated Orbiter Landings (NNJ04HF51G)
  + Test of Interactions Between Midodrine as a Countermeasure Against Postflight Orthostatic Hypotension and Promethazine as an Anti-emetic (ROI_MIDO_PMZ)
  + Evaluation of the Kentavr as a Countermeasure to Orthostatic Intolerance (ROI_KENTAVR)
  + Haughton Mars Immune Assessment (HMIA) (ROI_DEVON)
  + Stability of Nutrition Compounds (SMO Stability)
  + Gender Differences in Bedrest: Autonomic and Neuroendocrine Changes and Vascular Responses in Lower and Upper Extremities (BEDREST0543)
  + Retention of Skeletal, Musculature, and Postural Status with a Non-Invasive, Extremely Low-Level Mechanical Signal: A Ground-Based Evaluation of Efficacy (BEDREST0035)
  + Oxidative Damage During a 12-day Saturation Dive (ROI_Nutrition)
  + Vitamin D Supplementation in an Antarctic Ground Analog of Space Flight: Study of Supplementation Protocol and Relationship to Immune System Function (ROI_Polar_II)
  + Methods for the Assessment of Gastrointestinal Physiology and Function in a Lunar Analog Environment (SmartPill)
  + Ambiguous Tilt and Translation Motion Cues After Space Flight (E136)
  + 3D Tissue Analogues For The Study Of Varicella-Zoster Virulence And Infectivity (ROI_VZV)
  + Consequences of Long-term Confinement and Hypobaric Hypoxia on Immunity in the Antarctic Concordia Environment (CHOICE)
  + Vitamin D Supplement Evaluation of Dosing Requirements (Vitamin_D_Dosing)
  + A Methods Validation Protocol for Estimating Gastroinestinal Motility and Drug-Induced Motility Changes (ROI_PILLCAM)
  + Otoacoustic Hearing Assessment of Space Station Crews (SMO 011)
  + Alternative Compression Garment (Flight Analog) (BEDREST_ACG)
  + The Multisystem Effect of Exercise Training/Nutritional Support During Prolonged Bed Rest Deconditioning: An Integrative Approach to Countermeasure Development for the Heart, Lungs, Muscles and Bones (NCC958CA00701)
  + A Low-Intensity Mechanical Countermeasure to Prohibit Osteoporosis in Astronauts During Long-Term Spaceflight (ILSRA-2001-079)
  + Bioavailability of Scopolamine Dosage Forms and of a Combination Dosage Form with Dextroamphetamine after Oral Administration to Human Subjects (ROI_SCOPDEX)
  + Retrospective Study of Serum Sclerostin Measurements in Bedrest Subjects (ROI_Sclerostin)