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Longitudinal Study of Astronaut Health (LSAH)

In 1992, the Longitudinal Study of Astronaut Health (LSAH) began to investigate the incidence of acute and chronic morbidity and mortality of astronauts to determine whether the unique occupational exposures encountered by astronauts are associated with increased risks of total or cause-specific morbidity and mortality.

The Longitudinal Study of Astronaut Health (LSAH) was a cohort study designed to investigate and describe the incidence of acute and chronic morbidity and mortality of astronauts and to determine whether the unique occupational exposures encountered by astronauts are associated with increased risks of either total or cause-specific morbidity or mortality.

Specifically, the primary a priori hypotheses to be tested were: 1) astronauts are at different risk of total morbidity (defined as rate of incident cases of diseases/disorders, rate of hospitalizations, and average number of hospitalization days per person), than ground-based employees; and 2) astronauts are at different risk of total mortality than ground-based employees. Risk was measured relative to civil service employees located at the Johnson Space Center (JSC) who work and live, at least for a time, in the same geographical area as the astronauts; who participate in the JSC Occupational Medicine Clinic (OMC) Employee Wellness Program by undergoing preventative health examinations; and who have volunteered to participate in the study.

All astronauts selected for the NASA astronaut program were followed as "exposed" subjects from selection through-out the course of the study. Civil service employees who receive routine annual physical examinations at the OMC are selected as comparison subjects using age, sex, and body mass index as selection criteria, and they are followed in the same manner as the astronauts. As new astronauts are selected, matching groups of comparison participants were identified and recruited. The ratio of participants was three comparison subjects for every one astronaut. Morbidity, mortality, physical examination, and laboratory data were collected utilizing medical records routinely collected at the Johnson Space Center, as well as medical consultant reports, hospital discharge summaries, death certificates, and, when available, autopsy reports. The data bases are useful as computerized medical records as well as for research purposes.

The personal medical data included in the data bases of the LSAH are protected by the Privacy Act of 1974 and by the additional Security procedures and Policies of the LSAH and the JSC Clinics. Individual participant data are not included in reports or publications; only group data are presented.

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Related Experiments
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  + Visual Acuity Changes in Shuttle Astronauts (LSAHNEWSV8_1)
  + Aging and Blood Pressure in Astronauts (LSAHNEWSV8_1_2)
  + Association Between Age and PSA Values in LSAH Participants (LSAHNEWSV5_2)
  + Asthma in the LSAH Population (LSAHNEWSV10_2_2)
  + Intraocular Pressure in the LSAH Population (LSAHNEWSV4_1_2)
  + Diabetes Among LSAH Participants (LSAHNEWSV9_1_2)
  + Physical Activity Profiles of LSAH Participants (LSAHNEWSV12_2)
  + Prevalence of Hypertension in LSAH Participants (LSAHNEWSV9_1_1)
  + Risk of Cancer Mortality Among LSAH Participants (LSAHNEWSV6_1)
  + Body Mass Index (BMI) in LSAH Participants (LSAHNEWSV4_1_1)
  + Reported Levels of Physical Activity by LSAH Participants (LSAHNEWSV9_2_1)
  + Serum CPK Reported in LSAH Participants (LSAHNEWSV4_1_3)
  + Smoking Prevalence of LSAH Participants (LSAHNEWSV10_2_1)
  + Thyroid Disease Investigated Among LSAH Population (LSAHNEWSV7_1_1)
  + Incidence of Colorectal Cancer in LSAH Participants (LSAHNEWSV8_2_2)
  + Pulmonary Function and Aging in LSAH Participants (LSAHNEWSV5_1)
  + Operational Monitoring of Blood Parameters for First Time Shuttle Flyers (LSAHNEWSV6_2)
  + Women Astronaut Health (LSAHNEWSV7_1_2)
  + Body Mass Changes in NASA/Mir Astronauts (LSAHNEWSV7_2_1)
  + Association Between Aging and Specific Physiological Measurements (LSAHNEWSV7_2_2)
  + Injury Rate of Shuttle Astronauts (LSAHNEWSV8_2_1)
  + Nutritional Intake of LSAH Participants (LSAHNEWSV10_1)
  + Aging and Cardiopulmonary Function (LSAHNEWSV9_2_2)
  + Physiological Variables of EVA Participants (LSAHNEWSV7_2_3)
  + Physiological Variables of EVA Participants--An Update (LSAHNEWSV11_1)
  + Surveillance of Health Risks Among Older Adults (LSAHNEWSV11_2_1)
  + Vision and Aging in the Astronaut Population (LSAHNEWSV11_2_2)
  + Dietary Calcium Intake in LSAH Participants and U.S. General Population (LSAHNEWSV13_2_2)
  + Bone Health and Physical Activity in LSAH Participants (LSAHNEWSV13_2_1)
  + Hearing Loss Among LSAH Participants (LSAHNEWSV14_1_1)
  + Overweight and Obesity in the LSAH Population (LSAHNEWSV13_1_2)
  + Dietary Fat Consumption of U.S. General Population and LSAH Participants (LSAHNEWSV13_1_1)
  + Colorectal Cancer in LSAH Participants and a Comparison Population (LSAHNEWSV16_2_1)
  + Longitudinal Study of Astronaut Health (LSAH)