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Biospecimen Sharing Program (BSP)

The Biospecimen Sharing Program (BSP) was developed to ensure that valuable tissue samples not used by the primary investigators could be distributed to other interested investigators. The primary objective of this program was to maximize scientific return from the specimens flown on SLS-1, with the secondary objective of encouraging broader participation of the research community in the Life Sciences Flight Experiments Program. The SLS-1 BSP was initially an extension of the joint US/USSR studies conducted on Cosmos flights. Following the incorporation of the Soviet experiments, several additional foreign experiments were accepted, as well as experiments from NIH, NASA and various universities.

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  + Role of DJ1 protein in dopamine dysregulation of the brain in spaceflight condition (ARC00XX226)
  + Effect of spaceflight on mouse mandibular bone and teeth by MicroCT analysis (ARC00XX228)
  + Analysis of Bone Loss Resulting from 33 Days in Microgravity (ARC00XX211)
  + Collection of Immune/Stress-related Tissues from Mice Flown on ISS (NNX15AB45G )
  + Rodent spine deconditioning after 30 days of microgravity (ARC00XX57)
  + Microgravity May Detrimentally Influence Lipid Metabolism (ARC00XX185)
  + The effect of weightlessness on the tendon-to-bone insertion (ARC00XX67)
  + Temporal Transcriptomics Analysis of Archived Spaceflight Biological Samples from ALSDA from 1991 to 2016 (ARC00XX204)
  + Changes in Mouse Thymus and Spleen after Return from the STS-135 Mission in Space (ARC00XX95)
  + Long Term Space Flight Impacts on Male Reproductive Health (ARC00XX66)
  + The Response of Articular Cartilage to Microgravity (ARC00XX136)
  + Cellular and Molecular Mechanisms of Spaceflight-Induced Tissue Degeneration (ARC00XX77)
  + Protein Expression in Salivary Glands: Effects of Extended Space Flight (ARC00XX137)
  + Effects of Spaceflight on Ocular Oxidative Stress and the Blood-Retinal Barrier (NNX15AE86G)
  + Pilot Study of Otosclerosis (ARC00XX193)
  + Interrogating the Unfolded Protein Response in Microgravity-Induced Osteoporosis and Sarcopenia (ARC00XX189)
  + Influence of Spaceflight on the Production of Interleukin-3 and Interleukin-6 by Rat Spleen and Thymus Cells (PARE02 BSP3)
  + Characterization of the Retinal Glial Response to Spaceflight (ARC00XX11)
  + Biospecimen Sharing Program (9501264)
  + The Effect of Microgravity on mRNA Expression in the Vestibular Endorgans (2005006)
  + Biochemical Changes of Rat Bone Lipid Upon Space Flight (ARC00XX4)
  + Effects of Long Duration Space Travel on the Retina (BIO03008)
  + Effect of Spaceflight on Oxidative and Antioxidant Enzyme Activity in Rat Diaphragm and Intercostal Muscles (PARE02 BSP5)
  + Effects of Spaceflight on Morphology of the Rat Adenohypophysis (PARE02 BSP4)
  + Effects of Spaceflight Stress on Pro-opiomelanocortin, Proenkephalin A and Tachykinin Neurpepetidergic Systems in the Rat Posterior Pituitary (PARE02 BSP2)
  + Spaceflight Changes in Skeletal mRNA (PARE02 BSP1)
  + Osteoactivin: A novel glycoprotein inhibiting adhesion of osteoblastic cells to bone matrix (BIO03007)
  + Comparison of Oxidative Enzyme Activity in Motoneurons Between Cervical and Lumbar Segments in the Spinal Cord of Spaceflown Rats (BIO03005)
  + Effect of Space Environment on the Metabolism of Nicotinamide Adenine Dinucleotide (NAD) Metabolism in Rats (BIO03004)
  + Analysis of Gene and Protein Expressions of Cytochrome P450 and Stress Associated Molecules in Rat (BIO03002)
  + Effects of Spaceflight on Spermatogenesis in Rats - Expression and Quantification of Regulators or Modulators of Germ Cell Apoptosis Transcription Factors Implicated in Spermatogenesis (BIO03001)
  + Ultrastructure of the Brain Cortex (SLS1 BSP12)
  + Primary Perceptive Structure of the Brain: Morphology and Histochemistry (SLS1 BSP10)
  + Energy Metabolism Pathways in Rat Muscle under Conditions of Simulated Microgravity (TPS001)
  + Electron Microscopic Analysis of Archived Tissues (ARC00704)
  + The Effects of "Stretch" on the Normal Development of Cells and Tissues (ARC00XX2)
  + Histological Effects of Micro-G on Rat Body Wall Musculature (9302019)
  + Calbindins and Apoptosis After Short-term Spaceflight (NAG21194)
  + Vitamin D Endocrine System After Short-term Spaceflight (9302006)
  + The Effect of Spaceflight on Rodent Ocular Tissues (9302013)
  + Glial Cell Reaction from Spaceflight (9302008)
  + Effect of Spaceflight on Adrenal Medullary Functions (9302012)
  + Mitochondrial Changes in Muscle Following Spaceflight (9302002)
  + Is there a role for apoptosis with microgravity? (ARC00XX3)
  + Comparison of Ground and On-Orbit DNA Synthesis in Rat Gastric Epithelium During STS-54 (PARE02 BSP6)
  + Effect of SLS-2 Space Flight on Immunological Parameters of Rats: Bone and Immunity (SLS2 BSP13)
  + Effect of SLS-2 Space Flight on Immunological Parameters of Rats: Antiviral Immunity (SLS2 BSP12)
  + Metabolic and Structural Changes in Bone and Systems Regulating Bone Growth and Metabolism (SLS1 BSP3)
  + Morphology of Neurons of the Brain Cortex (SLS1 BSP18)
  + Biochemical Assessment of Stress in Cardiac Tissue (9302017)
  + Analysis of Frozen Tissue by RNA (ARC00XX1)
  + Biosepcimen Sharing Program (BSP) Post Mission Analysis (PMA) (BSP_PMA)
  + Biological and metabolic response in STS-135 space-flown mouse skin (ARC00XX104)
  + Space Flight Effects on Mouse Reproductive Tissues (ARC00XX163)
  + Evaluation of Changes in Thymus and Spleenocytes After Spaceflight (ARC00XX99)
  + Synaptic Plasticity in Utricular Hair Cells (ARC00XX98)
  + Myosins and myomiRs: The effects of spaceflight on myosin heavy chain gene and microRNA expression in heart and skeletal muscle (ARC00XX97)
  + Rodent Tail and Brain Deconditioning after 10-15 Days of Microgravity (ARC00XX96)
  + Effect of Spaceflight on Lung Gene and Protein Expression Profiles (ARC00XX94)
  + Gene expression alterations in articular cartilage, skeletal muscle and skin exposed to microgravity (ARC00XX93)
  + Regional Arterial Remodeling Induced by Microgravity (ARC00XX92)
  + Inner Ear Otoconia Response in Mice to Microgravity and Hypergravity (ARC00XX91)
  + Skeletal Muscle Regeneration (ARC00XX90)
  + The Role of the p21/p53 Pathway in Spaceflight-Induced Tissue Degeneration (ARC00XX89)
  + Spaceflight Effects on the Mouse Retina: Histological, Gene Expression and Epigenetic Changes After Flight (ARC00XX119)
  + Unloading-Driven Regulation of Eukaryotic Translation Initiation Factor 2 Alpha (eIF2a) and Genes linked to Integrated Stress Response (ISR) in Mouse Bone Tissues (ARC00XX118)
  + Effect of Spaceflight on Expression of Metabolic Enzyme Genes in Mice (ARC00XX117)
  + The effect of weightlessness on the tendon-to-bone insertion (ARC00XX113)
  + Long Term Space Flight Impacts on Female Reproductive Health (ARC00XX111)
  + Evaluation of the Effect of Short-Duration Spaceflight on Hepatic Nutrition, Oxidative Damage, and Colon Microflora (ARC00XX110)
  + Examination of Splenic and Thymic Immune Function in Mice (ARC00XX109)
  + Effects of Spaceflight Environment on Immune Parameters (ARC00XX107)
  + Effect of Space Flight on Neurogenesis (ARC00XX106)
  + Protein Expression in Salivary Glands: Effects of Extended Spaceflight (Collection of Salivary Glands from Mice Flown on STS-135) (ARC00XX105)
  + Spaceflight effects on renal and intestinal transporters associated with osteopenia and kidney stone formation and regulation of renal glucose and lipid metabolism (ARC00XX102)
  + Does spaceflight alter SIRT3 activity and mitochondrial function in the liver (ARC00XX101)
  + Effect of exposure to microgravity on the fast-type neuromuscular unit (ARC00XX100)
  + Micromechanical properties and cytoskeleton of soleus and anterior tibial muscles after exposure to microgravity (ARC00XX126)
  + Spaceflight effects on the mouse retina: Histological, gene expression and epigenetic changes after flight (ARC00XX87)
  + The effect of weightlessness on the tendon-to-bone insertion (ARC00XX86)
  + Long Term Space Flight Impacts on Female Reproductive Health (ARC00XX85)
  + Protein Expression in Salivary Glands: Effects of Extended Space Flight (ARC00XX84)
  + Synaptic plasticity in mammalian vestibular maculae (ARC00XX83)
  + Rodent Tail and Brain Deconditioning after 10-15 Days of Microgravity (ARC00XX82)
  + Regional Arterial Remodeling Induced by Microgravity (ARC00XX80)
  + Inner Ear Otoconia Response to Microgravity (ARC00XX79)
  + The Role of the p21/p53 Pathway in Spaceflight-Induced Tissue Degeneration (ARC00XX78)
  + The Response of Articular Cartilage to Microgravity (ARC00XX138)
  + The effect of weightlessness on the tendon-to-bone insertion (ARC00XX125)
  + Long Term Space Flight Impacts on Female Reproductive Health (ARC00XX124)
  + Regional Arterial Remodeling Induced by Microgravity (ARC00XX121)
  + The Role of Artificial Gravity in Promoting Tissue-Regenerative Matrix-Integrin-Kinase Cell Signaling (ARC00XX120)
  + Rodent spine deconditioning after 30 days of microgravity (ARC00XX88)
  + The Response of Articular Cartilage to Microgravity (ARC00XX81)
  + Protein Expression in Salivary Glands: Effects of Extended Space Flight (ARC00XX62)
  + Synaptic plasticity in mammalian utricle (ARC00XX58)
  + Individual and group behavior of Bion-M1 rodents (ARC00XX72)
  + Synaptic plasticity in mammalian vestibular maculae (ARC00XX135)
  + Regional Arterial Remodeling Induced by Microgravity (ARC00XX55)
  + Examining the Effects of Spaceflight on GSK3 Activation in Murine Muscle (ARC00XX224)
  + Biomedical analyses of mice body hair exposed to the space flight (ARC00XX112)
  + Bone Remodeling Parameters and Estrogen-Receptor Alpha Levels in the Axial Skeleton During Long-Duration Spaceflight (ARC00XX184)
  + Intake and Hypergravity: Responses of Regulatory Genes (97NTSP01009)
  + Effects of Microgravity on the Body Wall Muscles in Rodents (97NTSP01008)
  + Effect of Space Flight on Adrenal Medullary Function (97NTSP01007)
  + Alterations In Skeletal Muscle Gene Expression In Relation To The Muscle (97NTSP01006)
  + Evaluation of Bone Mineral Density of the Femur and an Immunohistochemical Evaluation of the Skin From Rats from Neurolab Fatness, Food (97NTSP01005)
  + Reduction in Density and Expression of Vasopressin Receptors in the Kidneys of Rats Following Spaceflight (97NTSP01004)
  + Morphological and Molecular Markers of Skeletal Muscle Denervation during Recovery from Spaceflight (97NTSP01003)
  + Mechanisms Underlying Loss of Proprioception (97NTSP01002)
  + Apoptosis in Microgravity-Sensitive Cells After Space Flight (97NTSP01001)