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Biospecimen Sharing Program (BSP)

The Biospecimen Sharing Program (BSP) was developed to ensure that valuable tissue samples not used by the primary investigators could be distributed to other interested investigators. The primary objective of this program was to maximize scientific return from the specimens flown on SLS-1, with the secondary objective of encouraging broader participation of the research community in the Life Sciences Flight Experiments Program. The SLS-1 BSP was initially an extension of the joint US/USSR studies conducted on Cosmos flights. Following the incorporation of the Soviet experiments, several additional foreign experiments were accepted, as well as experiments from NIH, NASA and various universities.

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  + Apoptosis in Microgravity-Sensitive Cells After Space Flight (97NTSP01001)
  + Mechanisms Underlying Loss of Proprioception (97NTSP01002)
  + Morphological and Molecular Markers of Skeletal Muscle Denervation during Recovery from Spaceflight (97NTSP01003)
  + Reduction in Density and Expression of Vasopressin Receptors in the Kidneys of Rats Following Spaceflight (97NTSP01004)
  + Evaluation of Bone Mineral Density of the Femur and an Immunohistochemical Evaluation of the Skin From Rats from Neurolab Fatness, Food (97NTSP01005)
  + Alterations In Skeletal Muscle Gene Expression In Relation To The Muscle (97NTSP01006)
  + Effect of Space Flight on Adrenal Medullary Function (97NTSP01007)
  + Effects of Microgravity on the Body Wall Muscles in Rodents (97NTSP01008)
  + Intake and Hypergravity: Responses of Regulatory Genes (97NTSP01009)
  + Bone Remodeling Parameters and Estrogen-Receptor Alpha Levels in the Axial Skeleton During Long-Duration Spaceflight (ARC00XX184)
  + Biomedical analyses of mice body hair exposed to the space flight (ARC00XX112)
  + Regional Arterial Remodeling Induced by Microgravity (ARC00XX55)
  + Synaptic plasticity in mammalian vestibular maculae (ARC00XX135)
  + Individual and group behavior of Bion-M1 rodents (ARC00XX72)
  + Synaptic plasticity in mammalian utricle (ARC00XX58)
  + Protein Expression in Salivary Glands: Effects of Extended Space Flight (ARC00XX62)
  + The Response of Articular Cartilage to Microgravity (ARC00XX81)
  + Rodent spine deconditioning after 30 days of microgravity (ARC00XX88)
  + The Role of Artificial Gravity in Promoting Tissue-Regenerative Matrix-Integrin-Kinase Cell Signaling (ARC00XX120)
  + Regional Arterial Remodeling Induced by Microgravity (ARC00XX121)
  + Long Term Space Flight Impacts on Female Reproductive Health (ARC00XX124)
  + The effect of weightlessness on the tendon-to-bone insertion (ARC00XX125)
  + The Response of Articular Cartilage to Microgravity (ARC00XX138)
  + The Role of the p21/p53 Pathway in Spaceflight-Induced Tissue Degeneration (ARC00XX78)
  + Inner Ear Otoconia Response to Microgravity (ARC00XX79)
  + Regional Arterial Remodeling Induced by Microgravity (ARC00XX80)
  + Rodent Tail and Brain Deconditioning after 10-15 Days of Microgravity (ARC00XX82)
  + Synaptic plasticity in mammalian vestibular maculae (ARC00XX83)
  + Protein Expression in Salivary Glands: Effects of Extended Space Flight (ARC00XX84)
  + Long Term Space Flight Impacts on Female Reproductive Health (ARC00XX85)
  + The effect of weightlessness on the tendon-to-bone insertion (ARC00XX86)
  + Spaceflight effects on the mouse retina: Histological, gene expression and epigenetic changes after flight (ARC00XX87)
  + Micromechanical properties and cytoskeleton of soleus and anterior tibial muscles after exposure to microgravity (ARC00XX126)
  + Effect of exposure to microgravity on the fast-type neuromuscular unit (ARC00XX100)
  + Does spaceflight alter SIRT3 activity and mitochondrial function in the liver (ARC00XX101)
  + Spaceflight effects on renal and intestinal transporters associated with osteopenia and kidney stone formation and regulation of renal glucose and lipid metabolism (ARC00XX102)
  + Protein Expression in Salivary Glands: Effects of Extended Spaceflight (Collection of Salivary Glands from Mice Flown on STS-135) (ARC00XX105)
  + Effect of Space Flight on Neurogenesis (ARC00XX106)
  + Effects of Spaceflight Environment on Immune Parameters (ARC00XX107)
  + Examination of Splenic and Thymic Immune Function in Mice (ARC00XX109)
  + Evaluation of the Effect of Short-Duration Spaceflight on Hepatic Nutrition, Oxidative Damage, and Colon Microflora (ARC00XX110)
  + Long Term Space Flight Impacts on Female Reproductive Health (ARC00XX111)
  + The effect of weightlessness on the tendon-to-bone insertion (ARC00XX113)
  + Effect of Spaceflight on Expression of Metabolic Enzyme Genes in Mice (ARC00XX117)
  + Unloading-Driven Regulation of Eukaryotic Translation Initiation Factor 2 Alpha (eIF2a) and Genes linked to Integrated Stress Response (ISR) in Mouse Bone Tissues (ARC00XX118)
  + Spaceflight Effects on the Mouse Retina: Histological, Gene Expression and Epigenetic Changes After Flight (ARC00XX119)
  + The Role of the p21/p53 Pathway in Spaceflight-Induced Tissue Degeneration (ARC00XX89)
  + Skeletal Muscle Regeneration (ARC00XX90)
  + Inner Ear Otoconia Response in Mice to Microgravity and Hypergravity (ARC00XX91)
  + Regional Arterial Remodeling Induced by Microgravity (ARC00XX92)
  + Gene expression alterations in articular cartilage, skeletal muscle and skin exposed to microgravity (ARC00XX93)
  + Effect of Spaceflight on Lung Gene and Protein Expression Profiles (ARC00XX94)
  + Rodent Tail and Brain Deconditioning after 10-15 Days of Microgravity (ARC00XX96)
  + Myosins and myomiRs: The effects of spaceflight on myosin heavy chain gene and microRNA expression in heart and skeletal muscle (ARC00XX97)
  + Synaptic Plasticity in Utricular Hair Cells (ARC00XX98)
  + Evaluation of Changes in Thymus and Spleenocytes After Spaceflight (ARC00XX99)
  + Space Flight Effects on Mouse Reproductive Tissues (ARC00XX163)
  + Biological and metabolic response in STS-135 space-flown mouse skin (ARC00XX104)
  + Biosepcimen Sharing Program (BSP) Post Mission Analysis (PMA) (BSP_PMA)
  + Analysis of Frozen Tissue by RNA (ARC00XX1)
  + Biochemical Assessment of Stress in Cardiac Tissue (9302017)
  + Comparison of Ground and On-Orbit DNA Synthesis in Rat Gastric Epithelium During STS-54 (PARE02 BSP6)
  + Is there a role for apoptosis with microgravity? (ARC00XX3)
  + Mitochondrial Changes in Muscle Following Spaceflight (9302002)
  + Effect of Spaceflight on Adrenal Medullary Functions (9302012)
  + Glial Cell Reaction from Spaceflight (9302008)
  + The Effect of Spaceflight on Rodent Ocular Tissues (9302013)
  + Vitamin D Endocrine System After Short-term Spaceflight (9302006)
  + Calbindins and Apoptosis After Short-term Spaceflight (NAG21194)
  + Histological Effects of Micro-G on Rat Body Wall Musculature (9302019)
  + The Effects of "Stretch" on the Normal Development of Cells and Tissues (ARC00XX2)
  + Electron Microscopic Analysis of Archived Tissues (ARC00704)
  + Energy Metabolism Pathways in Rat Muscle under Conditions of Simulated Microgravity (TPS001)
  + Primary Perceptive Structure of the Brain: Morphology and Histochemistry (SLS1 BSP10)
  + Ultrastructure of the Brain Cortex (SLS1 BSP12)
  + Morphology of Neurons of the Brain Cortex (SLS1 BSP18)
  + Metabolic and Structural Changes in Bone and Systems Regulating Bone Growth and Metabolism (SLS1 BSP3)
  + Effect of SLS-2 Space Flight on Immunological Parameters of Rats: Antiviral Immunity (SLS2 BSP12)
  + Effect of SLS-2 Space Flight on Immunological Parameters of Rats: Bone and Immunity (SLS2 BSP13)
  + Effects of Spaceflight on Spermatogenesis in Rats - Expression and Quantification of Regulators or Modulators of Germ Cell Apoptosis Transcription Factors Implicated in Spermatogenesis (BIO03001)
  + Analysis of Gene and Protein Expressions of Cytochrome P450 and Stress Associated Molecules in Rat (BIO03002)
  + Effect of Space Environment on the Metabolism of Nicotinamide Adenine Dinucleotide (NAD) Metabolism in Rats (BIO03004)
  + Comparison of Oxidative Enzyme Activity in Motoneurons Between Cervical and Lumbar Segments in the Spinal Cord of Spaceflown Rats (BIO03005)
  + Osteoactivin: A novel glycoprotein inhibiting adhesion of osteoblastic cells to bone matrix (BIO03007)
  + Spaceflight Changes in Skeletal mRNA (PARE02 BSP1)
  + Effects of Spaceflight Stress on Pro-opiomelanocortin, Proenkephalin A and Tachykinin Neurpepetidergic Systems in the Rat Posterior Pituitary (PARE02 BSP2)
  + Effects of Spaceflight on Morphology of the Rat Adenohypophysis (PARE02 BSP4)
  + Effect of Spaceflight on Oxidative and Antioxidant Enzyme Activity in Rat Diaphragm and Intercostal Muscles (PARE02 BSP5)
  + Effects of Long Duration Space Travel on the Retina (BIO03008)
  + Biochemical Changes of Rat Bone Lipid Upon Space Flight (ARC00XX4)
  + The Effect of Microgravity on mRNA Expression in the Vestibular Endorgans (2005006)
  + Biospecimen Sharing Program (9501264)
  + Characterization of the Retinal Glial Response to Spaceflight (ARC00XX11)
  + Influence of Spaceflight on the Production of Interleukin-3 and Interleukin-6 by Rat Spleen and Thymus Cells (PARE02 BSP3)
  + Interrogating the Unfolded Protein Response in Microgravity-Induced Osteoporosis and Sarcopenia (ARC00XX189)
  + Pilot Study of Otosclerosis (ARC00XX193)
  + Effects of Spaceflight on Ocular Oxidative Stress and the Blood-Retinal Barrier (NNX15AE86G)
  + Protein Expression in Salivary Glands: Effects of Extended Space Flight (ARC00XX137)
  + Cellular and Molecular Mechanisms of Spaceflight-Induced Tissue Degeneration (ARC00XX77)
  + The Response of Articular Cartilage to Microgravity (ARC00XX136)
  + Long Term Space Flight Impacts on Male Reproductive Health (ARC00XX66)
  + Changes in Mouse Thymus and Spleen after Return from the STS-135 Mission in Space (ARC00XX95)
  + Temporal Transcriptomics Analysis of Archived Spaceflight Biological Samples from ALSDA from 1991 to 2016 (ARC00XX204)
  + The effect of weightlessness on the tendon-to-bone insertion (ARC00XX67)
  + Microgravity May Detrimentally Influence Lipid Metabolism (ARC00XX185)
  + Rodent spine deconditioning after 30 days of microgravity (ARC00XX57)
  + Collection of Immune/Stress-related Tissues from Mice Flown on ISS (NNX15AB45G )
  + Analysis of Bone Loss Resulting from 33 Days in Microgravity (ARC00XX211)