The HERA facility is located at the Johnson Space Center in Houston, Texas and consists of a unique three-story closed habitat that is designed to serve as an analog for isolation, confinement, and remote conditions in exploration scenarios. Subjects’ emotional and mental states in a short-duration, isolated, and confined environment are captured to advance understanding of behavioral risks associated with this type of spaceflight analog. The two areas of study are behavioral health and biochemistry, which monitor subjects’ psychological health and cortisol levels, respectively.